It should be diagnosed only in a well sampled tumour removed totally and thorough microscopic examination is needed since the diagnosis can be made only by histopathology. Borderline tumors of the ovary also called tumors of lowmalignant potential are a heterogeneous group of lesions defined histologically by atypical epithelial proliferation without stromal invasion. Although ovarian ectopic pregnancy is rare, nevertheless, it is an important source of morbidity for women of childbearing age. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. We describe a case of adenofibroma discovered incidentally while investigating for a hydrocoele in a 57yearold patient. These tumors can be predominantly cystic, complex cystic with variable amounts of solid components or predominantly solid. Serous papillary cystadenofibroma of the fallopian tube. Adenofibromas can arise in the uterus 187,188 and, less often, in the endocervix. Ovaries also have an endocrine function they release oestrogen and progesterone. All ovarian tumors orig inally diagnosed as clear cell af, aptborderline tumor tumor of low malignant potential. According to the world health organization who classification, benign tumors of the fallopian tube comprise papilloma, cystadenoma, adenofibroma, cystadenofibroma caf, metaplastic papillary tumor and endometrioid polyp. Only one reference is available of occurrence of adenofibroma in three cases of lungs, of which.
Ovarian carcinoma is traditionally referred to as a single entity, but it consists of a heterogeneous group of neoplasms with multiple histologic subtypes. Teri a longacre, c blake gilks, in gynecologic pathology, 2009. Adenofibroma definition of adenofibroma by medical. Clear cell adenofibroma ccaf is a major benign or borderline type of ovarian clear cell tumor. Whereas adenofibromas of mullerian derivatives are well described, testicular tumours resembling surface ovarian epithelium are rare. To determine the origin of estradiol production in the tumor, stromal. Endometrioid adenofibroma cystadenofibroma is composed of wellspaced glands that vary in number, size and shape and are embedded in a fibromatous stroma. Ovarian borderline tumours are relatively uncommon but not rare neoplasms.
Clear cell carcinoma arising in vulvar endometriosis histopathological analysis of the 2 false positive pem cases revealed that they are one case of inflammatory lesion and one case of adenofibroma, suggesting that benign mammary abnormalities. The treatment for benign serous cystadenofibroma of ovary is complete surgical removal of the tumor. Webpathology is a free educational resource with 10304 high quality pathology images of benign and malignant neoplasms and related entities. Serous papillary caf spcaf is a rare tumor of the fallopian. Cystadenofibroma of the ovary wiley online library. The uterus is a muscular organ, and its mucosal lining undergoes hormone dependent changes. An ovarian adenofibroma is a type of ovarian epithelial tumor. Brief report adenofibroma of uterus and endocervix p. Histopathology salivary glandpleomorphic adenoma mixed tu. A the glands show a greater degree of crowding and variation in size and shape compared with clear cell adenofibroma. One study demonstrated the coexistence of ccaf components 14 cases in 21%. Pathogenesis of ovarian clear cell adenofibroma, atypical. The genital tract makes up the rest of the female reproductive system.
Adenofibromas of the testicular parenchyma are exceptional with only one case published in the literature. Vaginal cytologic analysis showed estrogenic effects, and endometrial cystic glandular hyperplasia was thought to be the reason for genital bleeding. Serous epithelium transformation into endometrioid glandular epithelium was disclosed. The surface of the ovary is covered by a single layer of cuboidal. Many authors however overlap this entity with an ovarian cystadenofibroma and consider these tumors often as part of an adenofibroma cystadenofibroma spectrum pathology. Department of pathology, harvard medical school, boston, massachusetts.
More recently, a few sporadic cases of adenofibroma have been reported mainly located in female genital tract e. Ovaries are situated one on each side of uterus close to lateral pelvic wall. During the last few years, however, there has been a dramatic shift in thinking, and a candidate precursor is now. With prompt and appropriate treatment, the prognosis is generally excellent. The pathological diagnosis was borderline clear cell adenofibroma of the left ovary. Given its size, solid components, and enhancment characteristics, surgical excision was recommended. Histological and epidemiological analyses have demonstrated a close relationship between endometriosis and ovarian clear cell adenocarcinoma ccac. Serous adenofibromas hard, white predominantly fibromatous tumours. The cortex of the ovary has numerous primordial germ cells with relatively little stroma. Borderline clear cell tumor of the ovary is defined as a tumor that is.
Associated squamous differentiation, endometrioid adenofibroma and endometrioid or mixed mullerian borderline tumor cefs were not present in any case, but 6% of patients had endometriosis. The differential diagnosis of ovarian adenofibroma should include ovarian masses with fibrous components, including fibroma, fibrothecoma and brenners tumor. Home liver and intrahepatic bile ducts tumor biliary adenofibroma. The glands are lined by columnar to cuboidal cells with eosinophilic cytoplasm and oval, small, and uniform neclei without appreciable mitotic activity. Cystadenofibroma of the ovary, a relatively rare benign tumor, usually appears during the fourth and fifth decades. Benign serous tumours serous cystadenoma unilocular thin walled cysts filled with clear fluid. Clear cell adenocarcinoma arising from adenofibroma in a. The remaining 10% originate either from the germ cells or sex cordstromal cells. Morphological and immunohistochemical reevaluation of. Clearcell adenofibroma can be a clonal precursor for clearcell adenocarcinoma of the ovary. Its incidence is on rise following the use of ovulationinducing. This tumor must be distinguished from other malignant lesions of the uterus, particularly adenosarcoma.
An eccentric presentation samarth shukla 1, deepti srivastava 2, sourya acharya 3, shweta dhote 1, sunita vagha 1 1 department of pathology, jawaharlal nehru medical college, datta meghe institute of medical sciences university, sawangi, wardha, maharashtra, india 2 department of obstetrics and gynecology, jawaharlal nehru medical college, datta meghe institute of. Sometimes solid fibrous parts dont have a low signal intensity on the t2 weighted images and they can show enhancement after the administration of contrast material. Kietpeerakool, borderline clear cell adenofibroma of the ovary, case reports in pathology, vol. Cystadenofibroma of the ovary in young women european journal. This is a common benign ovarian tumor diagnosed by. Adenofibroma of uterus and endocervix, histopathology 10. The ovary is where oogenesis occurs ovaries are stimulated by gonadotrophin from the anterior pituitary. Adenofibroma is a benign tumour, by definition, that consists of glands adeno and a fibrous stroma. Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more.
Ovarian cystadenofibroma is an uncommon benign neoplasm containing epithelial and fibrous stromal components, accounting for 1. Intestinal adenocarcinoma metastatic to ovary predominantly large intestine colorectal most common metastatic tumor involving ovary can mimic endometrioid and mucinous carcinomas of the ovary may present with elevated ca125 may first present with an ovarian mass intestinal adenocarcinoma metastatic to ovary. The clinical features of the patients with cystadenofibromas were similar to thos. We present five cases of young patients with cystadenofibromas of the ovary. It was classified as figo serous ia 2 ovarian tumors. Ovarian tumours tumour of the ovary are common form of neoplasia in women accounts for 3% of all cancers in females 80% are benign more common in older white women of northern european ancestry 90% of malignancies are. Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative borderline tumor, and carcinoma. Differential considerations ovarian cystadenofibroma ovarian cystadenocarcinoma sclerosing stromal tumor of the ovary ovarian masses with f. Adenofibroma is a benign polypoid mass composed of broad papillary fronds projecting from the surface and into cystic spaces. Ovary, fallopian tube and primary peritoneal carcinoma. Borderline clear cell adenofibroma of the ovary ncbi. The content on this site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Ovarian papillary adenofibroma what does the doctor say. Lined by ciliated columnar epithelium similar to fallopian tube.
A case of ovarian endometrioid adenofibroma of borderline malignancy with an increased serum estradiol level, which rapidly disappeared after removal of the tumor, is reported. Age and sex distribution benign serous cystadenofibroma of ovary can occur worldwide in women of any age, race or. Adenofibroma of the testis journal of clinical pathology. Adenofibromas are benign compound tumors composed of intermingling neoplastic epithelial cells as well as fibroblasts which are present in varying proportions. Noel weidner, in modern surgical pathology second edition, 2009. Serous borderline tumours one or more cysts lined by. Ovary, fallopian tube and primary peritoneal carcinoma histopathology reporting guide version 1. Ovarian serous cystadenofibroma is a subset of epithelial ovarian neoplasms that is. Endometrial adenofibroma is an uncommon mullerian mixed tumor composed of benign epithelial and mesenchymal components. A case of ovarian endometrioid adenofibroma of borderline. The ovarian stroma is more abundant in the medulla, where the larger follicles are seen. Tumors of the fallopian tube more details are uncommon and are the rarest tumors of the female genital tract.
A large majority are of serous or mucinous type with other morphological variants being much more uncommon. The behavior of these tumors is distinct from lowgrade ovarian carcinoma and they are considered a. The clinicopathologic features of 34 cystadenofibromas were analyzed and compared to those of 39 serous cystadenomas. This is a case report of malignant endometrioid adenofibroma of the ovary with serous cystadenoma in a 42. Webpathology is a free educational resource with 10334 high quality pathology images of benign and malignant neoplasms and related entities. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease. Endometrioid adenofibroma clinmed international library. Adenofibroma is a benign tumour, by definition, that consists of glands adeno and a fibrous stroma they can arise anywhere in the muellerian tract. Only 27% had disease confined to the pelvis at presentation, 52% of tumors were unilateral and the median tumor size was 8 cm.
There was a predominant cystic component demonstrating lowsignal intensity on t1w and highsignal intensity on t2w images figure 2 a and andb. Adenofibroma is a benign form of mixed mesodermal tumor composed of an admixture of mullerian epithelium and stroma, both components being benign. It is covered by epithelium that is most often endometrioid, ciliated, or nondescript columnar to cuboidal cells. It is proposed that the tumour should be considered as a benign variant. Clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development chengquan zhao1,2. Smooth inner surface or polypoid excrescences which are firm if fibrous or soft if oedematous. Benign endometrioid adenofibroma of ovary is a slowgrowing tumor of the ovary. The present case is of an ovarian serous adenofibroma in a young. Both ovary should be of normal size or be enlarged because of. Serous surface papillary adenofibroma of the ovary. A case is presented in which a 60yearold woman with adenofibroma of endometrium. Tumor of the ovary not associated to borderline or endometrioid. The germinal epithelium of the ovary rests upon the ovarian stroma. Pdf pathogenesis of ovarian clear cell adenofibroma.
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